Operating under the Longs Drugs banner that CVS acquired in 2008, this 24-hour pharmacy at the base of the Waikiki Galleria Tower is the largest drugstore in central Waikiki and a lifesaver for visitors. The Kalakaua Avenue flagship carries a deep selection of reef-safe sunscreen, aloe, beach gear, travel-size toiletries, Hawaiian-made snacks, mac-nut chocolates, wine, and a full grocery aisle, alongside a licensed pharmacy filling prescriptions, dispensing vaccines, and handling minor health needs around the clock. Tourists love it for late-night ibuprofen, jet-lag melatonin, and souvenir shopping at prices well below the ABC Stores next door. Locals know to come here for the pharmacy staff, who get strong reviews for friendly bedside manner. The combination of full grocery, full pharmacy, and 24/7 hours makes it Waikiki's most useful single stop.
"Great spot to grab beach snacks and sandwiches before heading out, and the pharmacist Kathy gave me a flu shot so smoothly I barely felt it. Hard to beat 24 hours in the middle of Waikiki."